Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis

O Dandash; A Fornito; J Lee; RSE Keefe; MWL Chee; RA Adcock; C Pantelis; SJ Wood; BJ Harrison

Journal article

Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis

O Dandash, A Fornito, J Lee, RSE Keefe, MWL Chee, RA Adcock, C Pantelis, SJ Wood, BJ Harrison

Schizophrenia Bulletin | Published : 2014

DOI: 10.1093/schbul/sbt093

Abstract

Recent functional imaging work in individuals experiencing an at-risk mental state (ARMS) for psychosis has implicated dorsal striatal abnormalities in the emergence of psychotic symptoms, contrasting with earlier findings implicating the ventral striatum. Our aims here were to characterize putative dorsal and ventral striatal circuit-level abnormalities in ARMS individuals using resting-state functional magnetic resonance imaging (fMRI) and to investigate their relationship to positive psychotic symptoms. Resting-state fMRI was acquired in 74 ARMS subjects and 35 matched healthy controls. An established method for mapping ventral and dorsal striatal functional connectivity was used to exami..

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University of Melbourne Researchers

Orwa Dandash Author

Christos Pantelis Author

Stephen Wood Author

Ben Harrison Author

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Grants

Funding Acknowledgements

National Research Foundation Singapore under the National Medical Research Council Translational and Clinical Research Flagship Program (NMRC/TCR/003/2008). The Australian Postgraduate Award (2010); the Melbourne Neuropsychiatry Centre Research Higher Degree Award (2010) to O.D.; CR Roper Fellowship and National Health and Medical Research Council Project Grant (1050504 to A.F.); Department of Veteran's Affair; Feinstein Institute for Medical Research; GlaxoSmithKline; National Institute of Mental Health; Novartis; Psychogenics; Research Foundation for Mental Hygiene, Inc; the Singapore National Medical Research Council (to R.S.E.K.); National Health and Medical Research Counsel of Australia Senior Principal Research Fellowship (628386 to C.P.); National Health and Medical Research Counsel of Australia Program Grant (566529 to C.P.); National Health and Medical Research Council of Australia Clinical Career Development Award (628509 to B.J.H.).